We discussed the results of a randomized study on Azacitidine with or  without eltrombopag for first-line treatment of intermediate- or  high-risk MDS with thrombocytopenia. The study was closed premature because of a negative effect of  eltromombag both on thrombocytopenia and time to progress to AML. Presenter: Prof. Spyridonidis Participants: Dr...

The updated results of the Aethera study were presented which confirmed  the effect of consolidation on PFS. Presenter: Prof. Spyridonidis Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Bountouris.

1. The optimal time for MRD testing may depend on the type of MRD. CBFB-MYH11 AML displayed a slower clone regrowth than AML with the other molecular signatures and recommended MRD testing for CBFB-MYH11 be performed every 6 months, whereas testing for PML-RARA MRD was recommended for every 2 months.   2. Another subject of...

We discussed a paper in which the authors measured MRD in AML by NGS  before allo Tx. They could perfom MRD analysis in most cases and MRD by  NGS proved the strongest factor for relapse post HCT. Presenter:  Prof. Spyridonidis Participants: Dr Liga, Dr Spyridis, Dr Lekka,...

We updated the current options for the treatment of CNS NHL and reviewed a  patient series (5 pts) treated with nivolumab for rrCNS NHL. Presenter: Prof. Spyridonidis Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Bountouris

The mechanisms of glucocorticoid induced leukocytosis were revealed during the discussion. TITLE: A general review of the mechanisms for steroid or glucocorticoid induced increases in the white blood cell count, Anthony J Busty, MD, PharmD, FNLA, FAHA.  Link: https://www.ebmconsult.com/articles/steroids-glucocorticoids-wbc-neutrophiles-increase Presenter:Dr Bountouris Participants: Prof. Spyridonidis, Dr Liga, Dr Spyridis,...

The treatment of DCIS T2N0M0 type of breast cancer was discussed and it was noted that after total mastectomy radiation is not needed. Presenter: Dr Bountouris Participants: Prof. Spyridonidis, Dr Liga, Dr Spyridis, Dr Lekka.

We discussed the evaluation and differential diagnosis of pineal tumors in adults, focusing on the pinocytomas.   Presenter: Dr Bountouris. Participants: Prof.Spyridonidis, Dr Liga, Dr Spyridis, Dr Lekka.

The excellent review from Zeieser and  Blazar on chronic GvHD published  in NEJM was discussed. Presenter: Prof. Spyridonidis Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Bountouris

We discussed the central role of B cell activation in chronic GVHD and  discussed the results of ibrutinib in cGVHD which led to FDA approval. Presenter: Prof. Spyridonidis Participants. Dr Liga, Dr Spyridis, Dr Lekka, Dr Bountouris

The excellent review from Zeieser and  Blazar on acute GvHD published in  NEJM was discussed. Presenter: Prof. Spyridonidis Participants: Dr Liga, Dr Spyridis, Dr Lekka, Dr Bountouris

We reviewed a case of AML with 11q23 abnormality involving the MLL gene and discussed the indication for transplant.   Presenter: Prof. Spyridondis Particiaptns: Dr Liga, Dr Spyridis, Dr Lekka, Dr Bountouris  

We presented a retrospective study showing that from patients not  receiveing alllo-HCT at CR-1, at 10 years 16.6% of patients aged <60  years and 2.4% of those aged ≥60 years were alive and disease-free. This  disease-free AML group consisted predominantly of patients with  core-binding factor AML with t(8;21)(q22;q22) or  inv(16)(p13q22)/t(16;16)(p13;q22) and...

Human herpesvirus 6 as a possible cause of pleuropericardial effusion in patients with hematologic malignacies after allogeneic transplantation.   Presenter: Dr Lekka Participants: Prof.Spyridonidis, Dr Liga, Dr Spyridis, Dr Bountouris

The study from the French group with positive results in gene therapy for Transfusion dependent Thalassemia patients was presented. We discussed the ended of conditioning in these patients with busulphan. Furthermore we discussed the need of busulphan levels in specific patients (eg children, thalssemia...

We discussed a case of isolated CNS relapse of an ALL ph + after BMT.  Interestingly the CNS relapse revealed with an AML clone. We discussed  the current literature. We specifically reviewed the cases in Table 3 of the paper attached. Presenter: Prof. Spyridonidis Participants: Dr Liga, Dr...

Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation Presenter: Dr Spyridis  Participants: Prof.Spyridonidis, Dr Liga, Dr Lekka, Dr Bountouris